Vitamin D3
as cholecalciferol
50 mcg
250% DV
Helps your body absorb calcium and supports normal immune function.*
NIH Office of Dietary Supplements
Nutrition
Start hereDUO Daily Essential
The everyday nutrients, plus digestive support, in one daily serving.
- Replenishes key vitamins & minerals*
- Eases digestion & soothes the gut*
- Supports steady energy & vitality*
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How subscribing works
Full terms- Delivered every month. Free shipping over $75.
- Skip or change the date from your account.
- Cancel online anytime.
- Save 20% on every delivery.
- Full Supplement Facts panel
- Formulated on published research
- Skip or cancel anytime
- Free shipping over $75
Why Daily Essential exists
Sound familiar?
Eating less changes more than your plate.
A few bites and I'm done.
Smaller meals leave less room for vitamins and minerals.
60%+ short on iron from food
Clin Obes 2026 · Read
I'm eating less, but am I eating enough?
You're not imagining it. One study measured 271 fewer calories at a single meal.
−271 kcal at a meal
Diabetes Metab Syndr 2026 · Read
Nobody told me what to eat with this.
You're not alone. Four medical societies now say nutrition belongs in GLP-1 care.
4 societies agree
Am J Clin Nutr 2025 · Read
Built by a family that's been through it. Read our story
Quotes describe common experiences. Studies aren't of DUO products. All research
Is this right for me?
Is Daily Essential right for you?
An honest answer, so you can decide with confidence.
You'll probably like it if
- Your plate got smaller.You’re eating less and want the basics covered.
- You want one simple step.One daily foundation, not a cabinet of bottles.
- You like knowing why.Every nutrient listed, in plain language.
DUO Daily Essential
from $47.20/mo · Helps fill everyday nutritional gaps.*
Check with your provider first if
- You’re pregnant, nursing or planning to be.
- You take prescription medication, including for diabetes or blood pressure.
- You have a medical condition or an upcoming procedure.
Still not sure? Ask us a question
DUO products are dietary supplements, not medications.
What's inside
Every nutrient has a job.
Per serving: 2 capsules ·
Vitamin B12
as methylcobalamin 1%
525 mcg
21,875% DV
Supports normal energy metabolism and red blood cell formation.*
Vitamin B12 is water-soluble - the body uses what it needs and clears the rest.
NIH Office of Dietary Supplements
Folate
as L-5-MTHF-Ca
400 mcg DFE
100% DV
Supports normal cell division and red blood cell formation.*
NIH Office of Dietary Supplements
Iron
as ferrous bisglycinate chelate
18 mg
100% DV
Supports normal oxygen transport in the blood.*
NIH Office of Dietary Supplements
Magnesium
as magnesium oxide and citrate
200 mg
48% DV
Involved in hundreds of enzyme reactions, including normal muscle and nerve function.*
NIH Office of Dietary Supplements
Zinc
as zinc bisglycinate chelate
20 mg
182% DV
Supports normal immune function and protein production.*
NIH Office of Dietary Supplements
Also insidePer serving%DV
Vitamin B6 (pyridoxal 5'-phosphate (P5P))26 mg1,500%
Biotin5 mcg17%
Digestive Comfort & Soothing Blend325 mg†
- Gingerols Ginger Root Extract
- Peppermint Extract
- Bromelain Powder
- DigeZyme
LactoSpore (Bacillus coagulans, 6 Billion CFU)166 mg†
Energy & Vitality Complex126 mg†
- Ashwagandha Extract
- Vitamin B12
- Vitamin B6
- Folate
Nutrient Replenishment Matrix22 mg†
BioPerine Black Pepper Extract (fruit)5 mg†
† Daily Value not established. Amounts inside blends aren't listed separately on the label.
Good to know
- • Contains iron. Keep out of reach of children.
- • Contains bromelain (from pineapple).
- • Includes ashwagandha. Check with your provider if pregnant or nursing.
- ✓ Gluten-free
- ✓ Lactose-free
- ✓ Vegetarian
- ✓ Non-GMO
- ✓ Alcohol-free
How to take it
Simple enough to keep doing.
Daily
From the label
As a dietary supplement, adults take two (2) capsules daily. For best results, take with 6-8 oz (177-237 ml) of water or as directed by healthcare professional.
Habit
Keep it consistent
Same time each day makes it easy to remember.
Meets the DUO Standard
If we can't explain why it's here, it doesn't belong here.
Our own internal standard. Not a third-party certification.
- 01Purposeful
- 02Evidence-led
- 03Transparent
- 04Tested
- 05Explainable
The Complete Routine · Best value
Four needs. One routine. Pay for three.
Daily Essential plus Gut, Hydration and Weight. The lowest-priced one is on us.
$125.60/ mo · $4.19 a day
Upgrade to the Complete Routine
Questions
Questions we'd ask if we were you.
Not necessarily. Some people cover their needs well from food alone. Eating less can make that harder for some people, and a simple daily foundation is one way to help fill everyday nutritional gaps.* Your healthcare provider can help you decide what's right for you.
Many people can. National nutrition surveys show that many adults still fall short on some nutrients from diet alone, and smaller portions can make that harder. Daily Essential is designed to help cover the everyday basics, not replace a balanced diet.
Talk to your healthcare provider or pharmacist before starting any supplement if you take medication. Bring the full Supplement Facts with you; you can find them above.
No. DUO is an independent dietary supplement brand. It is not affiliated with, endorsed by, or connected to any pharmaceutical company or prescription medication.
Ready when you are
Start with the essential.
One daily foundation for the nutrients that fall short when you eat less, with the full Supplement Facts panel.
Full Supplement Facts · Free shipping over $75 · Skip or cancel anytime
Want all four? Get the Complete Routine and pay for three
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Talk with your healthcare provider before starting any supplement, especially if you take medication.