Start hereDUO Daily Essential$47.20/mo
Everyday nutritional support.*
RESEARCH-BASED GLP-1 SUPPORT
Feel betterthrough yourGLP-1 journey.
Research-based nutrition support for the gaps that eating less can leave in nutrition, hydration, and digestion.
- 11published studies cited
- 480K+adults in the research
- 4medical societies’ guidance
- 11published studies cited
- 480K+adults in the research
- 4medical societies’ guidance
Built on research inN Engl J MedAm J Clin Nutr
Our core products
Start with the core.
Where most routines start.
Shop all1–1 of 8
Start here
Daily Multivitamin$36.00/mo
Everyday vitamins + minerals.*
Magnesium$38.40/mo
Calm muscles and restful sleep.*
Daily Energy Strips$35.20/mo
Everyday energy support, anywhere.*
Gut Support$36.80/mo
Daily digestion support.*
Daily Probiotic$38.40/mo
Daily gut balance.*
Digestive Support Strips$38.40/mo
Digestive support, anywhere.*
Daily Hydration$38.40/mo
Electrolytes for everyday hydration.*
74%Reported
74%Reported
Nearly 3 in 4 adults in a semaglutide trial reported digestive side effects.
Most reported: Nausea · Constipation · Diarrhea · Bloating
JW
John Wilding et al.
University of Liverpool · N Engl J Med 2021
STEP 1 trial. GI events were also common with placebo; most were mild and transient. Read the study
Why it matters
Eating less can leave real nutrition gaps.
Peer-reviewed · Authors shown are not affiliated with DUOSee all 11 studies
- Full Supplement Facts on every product
- Skip or cancel anytime
- Free shipping over $75
What DUO does
Your body will thank you.
Your GLP-1 does one job. DUO supports the rest, so you don't have to figure it all out yourself.Your GLP-1 does one job. DUO supports the rest: nutrition, digestion, hydration and your weight-management routine, so you don't have to figure it all out yourself.
1Step 1
Start with the essential.
One daily foundation for the nutrients that fall short when you eat less.
DUO Daily Essential
$47.20/mo
Helps fill everyday nutritional gaps.*
2Step 2
Get The Complete Routine.
The Complete Routine
$125.60/mo
All four areas covered: DUO Daily Essential, Gut Support, Daily Hydration and Metabolic Support. The lowest-priced one is on us.
NutritionGutHydrationWeight
Or add what you need.
Pick support for the areas that fit your journey.
Start here
DUO Daily Essential
Start with the essential, add what you need. Your everyday foundation, then the support that fits your journey.
- Replenishes key vitamins & minerals*
- Eases digestion & soothes the gut*
- Supports steady energy & vitality*
Subscribe monthlyEvery 30 days. Skip or cancel anytime.$47.20 / mo$1.57 a day
One-time purchaseOne 60-capsule bottle.$59.00$1.97 a day
Why a daily foundation
Four medical societies jointly published nutrition priorities for people on GLP-1 medications, including micronutrients and protein, and noted most patients don't receive adequate nutrition support.
Am J Clin Nutr \u00b7 2025 \u00b7 Clinical guidanceExplore the research
The complete routine · Best value
Four needs.
One routine.
Pay for three.
DUO Daily Essential plus Gut, Weight and Hydration, chosen to work together. Get all four and the lowest-priced one is on us, every month.
What's inside
4 products
DUO Daily Essential
Essentials · Everyday nutritional support.*
$59.00
Gut Support
Gut · Daily digestion support.*
$46.00
FREE
Daily Hydration · Peach Mango
Hydration · Electrolytes for everyday hydration.*
$48.00
Metabolic Support
· Daily support for your progress.*
$50.00
Bought separately$203.00
Bundle discount (lowest item free)−$46.00
Subscription discount (20%)−$31.40
You save$77.40
Subscribe monthlyEvery 30 days. Skip or cancel anytime.$125.60 /mo$4.19 a day
One-time purchaseOne month of all four.$157.00$5.23 a day
- Skip, swap, or cancel anytime
- Free shipping over $75
Prefer to start smaller? Start with Daily Essential
01 · Essentials
Micronutrients
When you're eating less, the basics get harder to cover.
02 · Gut
Digestion + enzymes
Digestion commonly changes during GLP-1 treatment.
03 · Hydration
Fluids + electrolytes
About 20% of daily fluid usually comes from food.
04 · Weight
Daily metabolic support
A botanical blend, taken alongside the rest.
From research to routine
Every product starts with a finding.
One published study for each area of support, and the DUO product built around it.
AreaThe researchWhat it foundWhat DUO does
Nutrition
13.6%
of GLP-1 users were vitamin D deficient at 12 months — nearly double the rate at 6 months.
Clin Obes · 2026 · Review, 480,825 adults · Read
So DUO includesDUO Daily EssentialVitamin D3 at 250% DV.*
$47.20/mo
Gut
74%
of adults in a semaglutide trial reported digestive side effects.
N Engl J Med · 2021 · STEP 1 trial · Read
So DUO includesDUO Gut SupportEnzymes, a probiotic and apple cider vinegar.*
$36.80/mo
Hydration
~20%
of the water you take in each day normally comes from food. Eat less, and that share shrinks.
National Academies · 2005 · Dietary Reference Intakes · Read
So DUO includesDUO Daily HydrationElectrolytes plus seven B vitamins.*
$38.40/mo
Body composition
~30%
of weight lost on GLP-1 therapy came from lean mass, not fat.
Obesity · 2025 · Meta-analysis, 7 RCTs · Read
So DUO includesCreatine + Hydration5 g creatine monohydrate per scoop.*
$46.40/mo
Studies describe intake and body composition in general or GLP-1 populations. They were not conducted on DUO products, and DUO is not affiliated with these publishers or authors. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Shop by need
One journey. Four types of support.
Your GLP-1 journey can affect more than your appetite. Start with the need that fits you.
Help cover your daily bases.
A reduced appetite can mean fewer chances to get the nutrients your body needs.
DUO Daily Essential
$47.20/mo
Research: 13.6% of GLP-1 users were vitamin D deficient at 12 months. Read
Shop essentials
Keep hydration within reach.
Eating and drinking patterns can change. Fluids and electrolytes, made easy.
Daily Hydration
$38.40/mo
Research: About 20% of daily fluid normally comes from food. Read
Shop hydration
Support the routine around the medication.
Nutrition, movement, and sustainable habits still matter.
Creatine + Hydration
$46.40/mo
Research: Trials report a notable share of weight lost is lean mass. Read
Shop weightWhy you can trust DUO
Know exactly what you're taking.
No hidden claims. Every claim on the bottle traces back to something you can check.
Full Supplement Facts
Full Supplement Facts on every product page.
View ingredientsSourced from established partners
Ingredients from established manufacturing partners.
Learn moreMade to recognized standards
Made in FDA-registered US facilities.
Our standardsTested for what matters
Tested for identity, potency and contaminants.
Quality & testingDUO products are dietary supplements, not medications. FDA registration does not mean FDA has tested or approved these products.
Built by a family that's been through it. Read our story
Learn
Know what's changing. Know what to support.
The research, made digestible. Every article lists its sources.
Essentials
Eating less? The nutrient gaps worth knowing about
Smaller portions can mean fewer vitamins and minerals. Here's which ones matter most.
Gut
Digestion on GLP-1: why your gut needs attention
How fiber, fluids, and everyday habits support regularity and comfort.
Hydration
Hydration is more than water
Eating and drinking less can reduce fluid and electrolyte intake.
Weight
Creatine, movement, and lean mass
Why creatine and simple daily habits matter while the number drops.
BETTER
TOGETHER.