Protease
In blendWhat it is
An enzyme that helps break down protein.
Why it's here
Supports the normal digestion of protein-rich foods.*
Gut
Digestive Support
A six-enzyme blend, taken before meals.
- Enhances nutrient absorption*
- Supports healthy digestion*
- Full-spectrum enzyme blend*
1
How subscribing works
Full terms- Delivered every 2 months. Free shipping over $75.
- Skip or change the date from your account.
- Cancel online anytime.
- Save 20% on every delivery.
- Full Supplement Facts panel
- Formulated on published research
- Skip or cancel anytime
- Free shipping over $75
Why Digestive Support exists
Sound familiar?
Eating less can change how digestion feels.
My digestion feels different now.
You're not imagining it. It's the most common change people report.
74% reported digestive changes
N Engl J Med 2021 · Read
Vegetables are the first thing I skip.
Less fiber on your plate means less for your gut.
None met daily fiber targets
Nutrients 2025 · Read
Nobody told me what to eat with this.
You're not alone. Four medical societies now say nutrition belongs in GLP-1 care.
4 societies agree
Am J Clin Nutr 2025 · Read
Built by a family that's been through it. Read our story
Quotes describe common experiences. Studies aren't of DUO products. All research
Is this right for me?
Is Digestive Support right for you?
An honest answer, so you can decide with confidence.
You'll probably like it if
- Your digestion feels different.You want simple daily support for your gut.
- Vegetables are the first to go.Smaller plates mean less fiber-rich food.
- You prefer one simple step.One daily capsule, not a cabinet of bottles.
Digestive Support
from $36.80/2 mo · Everyday digestive enzyme support.*
Check with your provider first if
- You’re pregnant, nursing or planning to be.
- You take prescription medication, including for diabetes or blood pressure.
- You have a medical condition or an upcoming procedure.
Still not sure? Ask us a question
DUO products are dietary supplements, not medications.
What's inside
Six enzymes, each with a job.
What each one is, and why it's here. Individual amounts inside the blend aren't listed on the label.
Per serving: 1 veggie capsule ·
Makzyme-Pro® enzyme blend · Proprietary blend
Six digestive enzymes that each break down a different part of a meal (2,500 HUT).
400 mg
From pineapple
Bromelain
In blendWhat it is
An enzyme that comes from pineapple stems.
Why it's here
Helps break down protein.*
From papaya
Papain
In blendWhat it is
An enzyme that comes from papaya.
Why it's here
Helps break down protein.*
Lipase
In blendWhat it is
An enzyme that helps break down fats.
Why it's here
Supports the normal digestion of fats.*
Breaks down milk sugar
Lactase
In blendWhat it is
An enzyme that breaks down lactose, the natural sugar in milk.
Why it's here
Supports the digestion of dairy.*
Beans & veggies
Alpha-galactosidase
In blendWhat it is
An enzyme that breaks down certain carbs found in beans and some vegetables.
Why it's here
Supports the digestion of beans and cruciferous vegetables.*
Good to know
- • Contains bromelain (from pineapple).
- ✓ Gluten-free
- ✓ Vegetarian
- ✓ Lactose-free
- ✓ Allergen-free
How to take it
Simple enough to keep doing.
Daily
From the label
Take one (1) capsule twice a day as a dietary supplement. For best results, take 20-30 min before a meal or as directed by your healthcare professional.
Habit
Keep it consistent
Same time each day makes it easy to remember.
Meets the DUO Standard
If we can't explain why it's here, it doesn't belong here.
Our own internal standard. Not a third-party certification.
- 01Purposeful
- 02Evidence-led
- 03Transparent
- 04Tested
- 05Explainable
Questions
Questions we'd ask if we were you.
Take one (1) capsule twice a day as a dietary supplement. For best results, take 20-30 min before a meal or as directed by your healthcare professional.
No. Every DUO product is sold on its own. The Complete Routine is for people who want all four areas covered at the best price.
Talk to your healthcare provider or pharmacist before starting any supplement if you take medication. Bring the full Supplement Facts with you; you can find them above.
No. DUO is an independent dietary supplement brand. It is not affiliated with, endorsed by, or connected to any pharmaceutical company or prescription medication.
Ready when you are
Add Digestive Support to your DUO.
A six-enzyme blend, taken before meals.
Full Supplement Facts · Free shipping over $75 · Skip or cancel anytime
Want every area covered? See the Complete Routine
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Talk with your healthcare provider before starting any supplement, especially if you take medication.